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KMID : 0362919880060020151
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Journal of the Korean Society for Therapeutic Radiology and Oncology
1988 Volume.6 No. 2 p.151 ~ p.154
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A Study on the Radiation Tumor Control Microscopic Tumors of the C3Hf/Sed Mouse Spontaneous Fibrosarcoma
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Ha Sung-Whan
Suit Herman D.
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Abstract
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To answer the question whether last clonogenic cell should be eradicated for the tumor to be controlled, radiation tumor control study was performed using microscopic tumors of variable sizes ranging from 101 to 105 tumor cells. TCD50’s estimated from experimental data were 14.8, 27.1, 42.4, 49.9 and 65.5 Gy for 101, 102, 103, 104 and 105 tumor cells, respectively. Theoretical calculations, assuming that all the clonogenic cells should be inactivated, were 15.65, 28.50, 40.97, 53.41 and 65.85 Gy.
From this well matched data, it can be concluded that all the clonogenic cells should be eradicated for tumor control, at least in this tumor model.
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KEYWORD
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Clonogenic cell, Microscopic, Fibrosacoma, Mouse
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